一种孔径和粒径均单分散可控的介孔硅快速止血粉及制备方法

Aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and preparation method

Abstract

The invention discloses an aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder and a preparation method. The preparation method includes: 1) adding cetyl trimethylammonium bromide into water, and conducting nitrogen purging under stirring; 2) under stirring, adding n-octane, methyl methacrylate, tetraethyl orthosilicate and azobis(isobutylamidine hydrochloride) into the liquid obtained in step 1) in order, using lysine or tris(hydroxymethyl)aminomethane to adjust pH, carrying out reaction, and then performing standing to obtain a milky white suspension; 3) centrifuging the milky white suspension, and conducting centrifugal washing with anhydrous ethanol; and 4) in an air atmosphere, conducting calcination to remove a mesoporous template to obtain the white aperture and particle size monodisperse controllable mesoporous silicon rapid hemostatic powder. The hemostatic powder provided by the invention can stop bleeding rapidly, and is suitable for pre-hospital emergency treatment of serious bleeding patients, and has the characteristics of very fast hemostatic rate, hemostatic effect superior to chitosan and kaolin products, good biological and tissue compatibility, and no side effect.
本发明公开了一种孔径和粒径均单分散可控的介孔硅快速止血粉及制备方法,制备方法为:1)向水中加入十六烷基三甲基溴化铵,搅拌的同时以氮气吹洗;2)在搅拌,向步骤1)获得的液体中依次加入正辛烷、甲基丙烯酸甲酯、正硅酸乙酯和偶氮二异丁脒盐酸盐,用赖氨酸或三(羟甲基)氨基甲烷调节pH,反应,再静置,得乳白色悬浮液;3)将乳白色悬浮液离心,用无水乙醇离心洗涤;4)在空气氛围,煅烧去除介孔模板,获得白色的孔径和粒径均单分散可控的介孔硅快速止血粉。本发明的止血粉能快速止血,适用于严重出血伤员的院前紧急救治。止血速率极快,止血效果优于壳聚糖和高岭土类产品,生物和组织相容性良好,无任何副作用。

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